• also known as myeloma or plasma cell myeloma. It is a progressive hematologic (blood) disease.
• It is characterized by excessive numbers of abnormal plasma cells in the bone marrow and overproduction of intact monoclonal immunoglobulin (IgG, IgA, IgD, or IgE) or Bence-Jones protein (free monoclonal κ and λ light chains).
• Hypercalcemia, anemia, renal damage, increased susceptibility to bacterial infection, and impaired production of normal immunoglobulin are common clinical manifestations of multiple myeloma.
• It is often also characterized by diffuse osteoporosis, usually in the pelvis, spine, ribs, and skull.
• Headache and bone pain
• Pathologic fractures
• Skeletal deformities of sternum and ribs
• Renal calculi
• Spinal cord compression
• Analgesics for bone pain
• Chemotheraphy (cyclophosphamide)
• Gamma Globulins
• Radiation Therapy
• Blood Transfusion
• Encourage ambulation to slow bone demineralization
• Encourage fluid intake (3-4 L/day)
• Avoidance of crowds or sources of infection
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